Hypothemycin normalized the morphology and inhibited anchorage-independent growth of Ki-ras transformed normal rat kidney(NRK) cells with selectivity and potency comparable to or greater than that of the MEK inhibitor U0126. It is also potent and selective threonine/tyrosine-specific kinase.
Hypothemycin inhibits proliferation of mouse and human T-cells and modulates production of cytokines during T-cell activation. It facilitates the ubiquitinylation process of cyclin D1.
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Product References
The Resorcylic Acid Lactone Hypothemycin Selectively Inhibits the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cells, Biol. Pharm, Hidesuke Fukazawa, 33(2) (2010)?
Gene for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia, Microbiol, Christopher D. Reeves, et al., vol. 74, no. 16 (2008)
Semiynthesis and Cytotoxicity of Hypothemycin Analogues, ChemMedChem, Brian R.Hearn Dr., et al., vol. 2 (2007)
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