Elasnin isolated from Streptomyces sp. markedly inhibits human granulocyte elastase(IC50=1.3μg/ml), but it is almost inactive against pancreatic elastase, chymotrypsin(IC50=82μg/ml), and trypsin.
The culture also produced anti-candida activity. The specific action of elasnin is interesting in connection with its potential application to acute arthritis, various inflammations, pulmonary emphysema, and pancreatitis. Elasnin may facilitate a better understanding of these disease processes.?
Elasnin is a neutral, colorless, and viscous oil.
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