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A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC= 14 nM). Displays 15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.

Additional Information

Synonyms	6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Product #	D-2295
CAS #	247016-69-9
Chemical Name	6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Formula	C15H18N6O.2HCl
MW	371.27
Appearance	White Solid
Purity	98% by HPLC
Solubility	DMSO (~100 mM) or EtOH (~ 100 mM)
Storage Temp	-20°C
Therapeutic Area	Endocrinological Disorders
Use	Inhibition of dipeptidyl peptidase IV (DPP-IV) has been used to the treatment of type 2 diabetes

Additional Information

MDL Number	MFCD12828773
ChemACX	X1764022-5
InChI	InChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20);2*1H/t13-;;/m0../s1
SMILES	C1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl