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PYR-41

品牌：AG Scientific

貨號：

規(guī)格：5 mg

貨期：

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CAS:418805-02-4Formula:C17H13N3O7MW:371.3Appearance:BrownSolidPurity:98%byTLC

商品詳情參考文獻相關(guān)資料

Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC< 10M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-B activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

Additional Information

Synonyms	4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Product #	P-2410
CAS #	418805-02-4
Chemical Name	4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Formula	C₁₇H₁₃N₃O₇
MW	371.3
Appearance	Brown Solid
Purity	98% by TLC
Solubility	DMSO (~25 mg/ml)
Melting Point	258.53 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	PYR 41 is an irreversible and cell-permeable UBE1 (ubiquitin-activating enzyme E1) inhibitor as therapeutics in cancer

Additional Information

MDL Number	MFCD01469983
ChemACX	X3304879-0
InChI	InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
SMILES	CCOC(=O)c1ccc(cc1)N2C(=O)/C(=C\c3ccc(o3)[N+](=O)[O-])/C(=O)N2

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