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Phorbol-12-myristate-13-acetate

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:16561-29-8Formula:C36H56O8MW:616.8Appearance:Whitetooff-whitesolid.Purity:>99.5%

商品詳情參考文獻相關(guān)資料

Potent mouse skin tumor promoter. Also activates Protein Kinase C.Frequent and Strong Antibody-Mediated Natural Killer Cell Activation in Response to HIV-1 Env in Individuals with Chronic HIV-1 Infection.HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function.Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes.A T-bet-Independent Role for IFN-/ in Regulating IL-2 Secretion in Human CD4+ Central Memory T Cells.Blockade of Virus Infection by Human CD4+ T Cells via a Cytokine Relay Network.

Additional Information

Synonyms	TPA, 12-OTetradecanoyl- phorbol 13-acetate, Phorbol myristate acetate
Product #	P-1039
CAS #	16561-29-8
Chemical Name	(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
Formula	C₃₆H₅₆O₈
MW	616.8
Appearance	White to off-white solid.
Purity	>99.5%
Solubility	Soluble in DMSO (100 mM), and ethanol
Melting Point	50-70 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	It is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia

Additional Information

Merck Index	Merck Index: 13.7417.2001
MDL Number	MFCD00036736
ChemACX	X1009782-4
InChI	InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1
SMILES	CCCCCCCCCCCCCC(=O)O[C@@H]2C(C)[C@]1(O)C4/C=C(/C)C(=O)[C@@]4(O)CC(CO)=C/[C@H]1[C@H]3[C@]2(OC(C)=O)C3(C)C