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Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNFdependent NF-B activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.

Additional Information

Synonyms	HWA486
Product #	L-2372
CAS #	75706-12-6
Chemical Name	5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
Formula	C12H9F3N2O2
MW	270.21
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (100 mM) or Ethanol (100 mM)
Melting Point	166.5 °C
Storage Temp	-20°C
Therapeutic Area	Autoimmune Diseases
Use	Leflunomide is an immunosuppressive drug that inhibits T and B cell responses.

Additional Information

MDL Number	MFCD00867593
ChemACX	X1063791-7
InChI	InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
SMILES	Cc1c(cno1)C(=O)Nc2ccc(cc2)C(F)(F)F