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Pro-drug form of FTI-276 that acts as a highly potent and selective inhibitor of FTase (IC = 50 nM). Inhibits H-Ras processing in whole cells (IC = 100 nM), but does not inhibit geranylgeranylated Rap1A processing.

Additional Information

Product #	F-1156
CAS #	170006-73-2
Formula	C22H29N3O3S2?xC2HF3O2
MW	447.6
Appearance	Off-white, waxy Solid
Purity	95% by HPLC
Solubility	DMSO (100 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.

Additional Information

MDL Number	MFCD00952925
ChemACX	X1868206-9
InChI	InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26)/t16-,20+/m1/s1
SMILES	COC(=O)[C@H](CCSC)NC(=O)c1ccc(cc1c2ccccc2)NC[C@H](CS)N