DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α?and inhibiting JMJD2A (IC50?= 2.5 μM). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation. DMOG prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage.
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