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Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC= 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated tubulin deacetylation in mammalian cells.

Additional Information

Synonyms	N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Product #	T-2471
CAS #	537049-40-4
Chemical Name	N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Formula	C41H43N3O7S
MW	721.86
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO (~ 10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A selective inhibitor of HDAC6 induces DNA damage and sensitizes transformed cells to anticancer agents

Additional Information

MDL Number	MFCD18452824
ChemACX	X1851075-3
InChI	InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
SMILES	c1ccc(cc1)c2c(oc(n2)SC[C@H]3C[C@H](O[C@H](O3)c4ccc(cc4)NC(=O)CCCCCCC(=O)NO)c5ccc(cc5)CO)c6ccccc6