A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α? trimer and promotin sbunit dissociation and preventing TNF-α? binding to its receptor (IC50 = 22 μM).? Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).
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