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*Please inquire the availability for this product. Tetromycin B is an unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.

Additional Information

Product #	T-2621
CAS #	180027-84-3
Formula	C34H46O5
MW	534.7
Appearance	Light tan solid
Purity	>99% by HPLC
Solubility	Soluble in ethanol, methanol, DMF, DMSO, and water (moderately)
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Tetromycin B has displayed pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA

Additional Information

MDL Number	MFCD00950447
InChI	InChI=1S/C34H46O5/c1-18-10-9-11-19(2)27-21(4)14-24-25(35)13-12-20(3)28(24)33(27,8)29(36)26-30(37)34(39-31(26)38)17-23(6)22(5)16-32(34,7)15-18/h11,14-16,20,23-25,27-28,35,37H,9-10,12-13,17H2,1-8H3/b18-15+,19-11+
SMILES	CC1CCC(C2C1C3(C(/C(=C/CC/C(=C/C4(C=C(C(CC45C(=C(C3=O)C(=O)O5)O)C)C)C)/C)/C)C(=C2)C)C)O