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Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumour growth. Survivin is highly expressed in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for for studying cancer therapy.

Additional Information

Product #	S-2156
MW	18.6 kDa
Purity	90% as determined by SDS-PAGE
Storage Temp	Aliquot and store at -80°C. Stable for 6-12 months. Avoid freeze/thaw cycles.

Additional Information

ChemACX	X1836945-4