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A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC= 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC= 12 M and 17 M, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 M), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from -irradiation-induced apoptosis with an ECof 3 M and 7.6 M, respectively.

Additional Information

Synonyms	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Product #	C-2264
Chemical Name	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Formula	C20H14CIN3O2
MW	363.8
Appearance	Pale yellow Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO (10 mg/ml)
Storage Temp	+4°C

Additional Information

MDL Number	MFCD08276917
ChemACX	X1835816-4
InChI	InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
SMILES	C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl