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Bestatin (Ubenimix)

品牌：AG Scientific

貨號(hào)：

規(guī)格：5 mg

貨期：

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CAS:58970-76-6Formula:C16H24N2O4MW:308.4Appearance:WhitesolidPurity:>98%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials. Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer¹p>.

1.) Tsukamoto H, Shibata K, Kajiyama H, Terauchi M, Nawa A,Kikkawa F. 2008. Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer. BMC Cancer. 8:74.

Additional Information

Synonyms	Ubenimix, Inobestin, NK 421, Leukotriene A4 hydrolase, Aminopeptidase N
Product #	B-2547
CAS #	58970-76-6
Formula	C₁₆H₂₄N₂O₄
MW	308.4
Appearance	White solid
Purity	>98% by HPLC
Solubility	Soluble in water (<1 25), dmso (2 mg>
Melting Point	233-236 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Bestatin is a potent aminopeptidase inhibitor use in cancer

Additional Information

MDL Number	MFCD00083262
InChI	InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O

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