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Cell-permeable. A potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a useful tool to study the Hh signaling pathway.

Additional Information

Synonyms	N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Product #	S-2424
CAS #	329196-48-7
Chemical Name	N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Formula	C26H26ClN3O4
MW	479.96
Appearance	White to off-white Solid
Purity	95% by NMR
Solubility	DMSO (100 mM) or EtOH (100 mM)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of Smo (Hedgehog signaling pathway) and SAG

Additional Information

MDL Number	MFCD01827636
ChemACX	X1833192-1
InChI	InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30)
SMILES	CCOc1cc(cc(c1OCC)OCC)C(=O)Nc2ccc(c(c2)c3[nH]c4ccccc4n3)Cl