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PI-103

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:371935-74-9Formula:C19H16N4O3MW:348.36Appearance:Off-WhiteSolidPurity:98%byHPLC

商品詳情參考文獻相關資料

A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110), and mTOR. The ICvalues are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110, mTORC1, PI3-KC2, p110, mTORC2, p110, and p110, respectively. Inhibits growth of human tumor xenografts in mice in vivo.

Additional Information

Synonyms	3-(4-(4-Morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Product #	P-2394
CAS #	371935-74-9
Chemical Name	3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Formula	C₁₉H₁₆N₄O₃
MW	348.36
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO (50 mM)
Melting Point	231.64 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in acute myelogenous leukemia (AML)

Additional Information

MDL Number	MFCD11983145
ChemACX	X1600468-5
InChI	InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
SMILES	C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O

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