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NVP-TAE684

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:761439-42-3Formula:C30H40ClN7O3SMW:614.2Appearance:LightyellowSolidPurity:98%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC= 2-10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK (Nucleophosmin-anaplastic lymphoma kinase) and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.

Additional Information

Synonyms	5-Chloro-N4-(2-(isopropylsulfonyl)phenyl-N2-(2-methoxy-4-(4-methylpiperazin-1-yl)-piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Product #	N-2369
CAS #	761439-42-3
Chemical Name	5-Chloro-N4-(2-(isopropylsulfonyl)phenyl-N2-(2-methoxy-4-(4-methylpiperazin-1-yl)-piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Formula	C₃₀H₄₀ClN₇O₃S
MW	614.2
Appearance	Light yellow Solid
Purity	98% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase use in cancer

Additional Information

MDL Number	MFCD11977634
ChemACX	X1754756-3
InChI	InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
SMILES	CC(C)S(=O)(=O)c1ccccc1Nc2c(cnc(n2)Nc3ccc(cc3OC)N4CCC(CC4)N5CCN(CC5)C)Cl

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