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Pharmacology: Itraconazole inhibits the conversion of lanosterol to ergosterol via inhibition?of the 14-α demethylase, a cytochrome P-450 enzyme¹.?

Clinically useful antifungal agent. It?inhibits the proliferation of glioblastoma cells in vitro and in vivo by inducing autophagic?progression?

via inhibiting the trafficking of cholesterol from late endosomes and lysosomes?to the plasma membrane².

Inhibits the hedgehog pathway by binding to Smoothened (SMO)?via a mechanism distinct from that of cyclopamine³?.?

Inhibits angiogenesis via inhibiting the?binding of VEGF to VEGFR2⁴

References:

1. H Vanden Bossche et al. Antimicrob. Agents Chemother. 1993 37:2101

2. R Liu et al. Autophagy 2014 10:1241

3. J Kim et al. Cancer Cell 2010 17:388

4. BA Nacev et al. J. Biol. Chem. 2011 286:44045

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