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Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC= 0.3 nM for totalamyloid) and Notch processing. At higher concentrations (20-400 M), only weakly affects the presenilase activity.

Additional Information

Synonyms	(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Product #	C-2269
CAS #	209986-17-4
Chemical Name	(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Formula	C27H24F2N4O3
MW	490.5
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (~ 10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	A potent and specific inhibitor of γ-secretase use in Alzheimer’s disease

Additional Information

MDL Number	MFCD04974531
ChemACX	X5572887-1
InChI	InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
SMILES	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F