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A synthetic peptide that irreversibly inhibits activity of caspase-3 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Additional Information

Synonyms	Biotin-DEVD-FMK, DEVD-FMK, Biotin-
Product #	B-2203
Chemical Name	Biotin-DEVD-FMK, DEVD-FMK, Biotin-
Formula	C38H60FN7O13S
MW	873.99
Appearance	Liquid
Purity	95% by HPLC
Storage Temp	-20°C

Additional Information

ChemACX	X1497846-0
InChI	InChI=1S/C38H60FN7O13S/c1-21(2)33(37(55)43-23(26(47)19-39)17-31(51)58-4)45-35(53)22(14-15-30(50)57-3)42-36(54)24(18-32(52)59-5)41-29(49)13-7-6-10-16-40-28(48)12-9-8-11-27-34-25(20-60-27)44-38(56)46-34/h21-25,27,33-34H,6-20H2,1-5H3,(H,40,48)(H,41,49)(H,42,54)(H,43,55)(H,45,53)(H2,44,46,56)
SMILES	CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2
Peptide Sequence	BIOTIN-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK