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BI-D1870

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:501437-28-1Formula:C19H23F2N5O2MW:391.42Appearance:PaleorangeSolidPurity:98%byTLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC's at 100 M ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser.

Additional Information

Synonyms	2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Product #	B-2201
CAS #	501437-28-1
Chemical Name	2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Formula	C₁₉H₂₃F₂N₅O₂
MW	391.42
Appearance	Pale orange Solid
Purity	98% by TLC
Solubility	Soluble in DMSO (>25 mg/ml)
Storage Temp	-20°C
Use	BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK)?

Additional Information

MDL Number	MFCD11223662
ChemACX	X1859206-0
InChI	InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
SMILES	CC1C(=O)N(c2cnc(nc2N1CCC(C)C)Nc3cc(c(c(c3)F)O)F)C

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