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Bestatin HCl

品牌：AG Scientific

貨號：

規(guī)格：5 mg

貨期：

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CAS:65391-42-6Formula:C16H24N2O4.HClMW:344.8Appearance:WhitepowderPurity:≥98%

商品詳情參考文獻(xiàn) 相關(guān)資料

Bestatin is a competitive, reversible protease inhibitor derived from Streptomyces olivoreticuli. Inhibits aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

It is being studied for use in the treatment of?acute myelocytic leukemia.

Additional Information

Synonyms	Aminopeptidase inhibitor; leucine aminopeptidase; aminopeptidase B; NK-421
Product #	B-1075
CAS #	65391-42-6
Chemical Name	(2S,3R)-3-Amino-2-hydroxy-4- phenylbutanoyl]-L-leucine . HCl
Formula	C₁₆H₂₄N₂O₄.HCl
MW	344.8
Appearance	White powder
Purity	≥98%
Solubility	Clear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.
Melting Point	213-215°C
Storage Temp	Store desiccated at -20°C. PROTECT FROM LIGHT!
Therapeutic Area	Oncological Disorders
Use	An inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase use in cancer

Additional Information

MDL Number	MFCD00058004
ChemACX	X1087674-3
InChI	InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl

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