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Axitinib

品牌：AG Scientific

貨號：

規(guī)格：5 mg

貨期：

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CAS:319460-85-0Formula:C22H18N4OSMW:386.473g/molAppearance:Whitetooff-whiteSolidPurity:99%byHPLC

商品詳情參考文獻相關(guān)資料

Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models and renal cell carcinoma (RCC) and several other tumor types.

Additional Information

Synonyms	AG-013736
Product #	A-2193
CAS #	319460-85-0
Chemical Name	N-METHYL-2-[[3-[(E)-2-PYRIDIN-2-YLETHENYL]-1H-INDAZOL-6-YL]SULFANYL]BENZAMIDE
Formula	C₂₂H₁₈N₄OS
MW	386.473g/mol
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO (10 mM)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of Flt and Flk (VEGFR) with antitumor properties

Additional Information

MDL Number	MFCD09837898
ChemACX	X1636542-9
InChI	InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
SMILES	CNC(=O)c1ccccc1Sc2ccc3c(c2)[nH]nc3/C=C/c4ccccn4

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