AG 1296 is a potent and selective inhibitor of PDGF receptor kinase, it inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem?cell factor receptor transfected cells. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.It also induces apoptosis in a small-cell lung cancer cell line (H526).?
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