ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, ICvalue of 4 nM), but has much less activity (ICvalues >1 M) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (ICvalues of 2, 4 and 7 nM for PDGFR, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM ICfor human endothelial cells).
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