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Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC= 0.560.04 M). Displays high selectivity (36-fold) over MDP-stimulated signaling in reporter cell lines containing both endogenous and overexpressed NOD2 proteins or TNF-induced NF-kB activation.

Additional Information

Synonyms	1-Tosyl-1H-benzo[d]imidazol-2-amine; Nodinitib-1
Product #	M-2383
CAS #	799264-47-4
Chemical Name	1-Tosyl-1H-benzo[d]imidazol-2-amine; Nodinitib-1
Formula	C14H13N3O2S
MW	287.34
Appearance	White Solid
Purity	97% by HPLC
Solubility	DMSO
Storage Temp	-20°C

Additional Information

MDL Number	MFCD04322367
ChemACX	X3939413-3
InChI	InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
SMILES	CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N