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Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110 (IC= 60 nM). Inhibits p110 and p110 only at higher concentrations (1 M). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 M.

Additional Information

Synonyms	2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
Product #	I-2356
CAS #	371242-69-2
Chemical Name	2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
Formula	C22H19N7O
MW	397.43
Appearance	White to off-white Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	IC-87114 selectively inhibits PI3K inhibitor with action against fMLP-PIP3.

Additional Information

MDL Number	MFCD09970845
ChemACX	X1812304-1
InChI	InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
SMILES	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C(N=CN=C54)N