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GDC-0449

品牌：AG Scientific

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規(guī)格：5 mg

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CAS:879085-55-9Formula:C19H14Cl2N2O3SMW:421.3Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

GDC-0449, Vismodegib is a potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. GDC-0449, Vismodegib inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.

Additional Information

Synonyms	2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691;Vismodegib
Product #	G-2334
CAS #	879085-55-9
Chemical Name	2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Formula	C₁₉H₁₄Cl₂N₂O₃S
MW	421.3
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell

Additional Information

MDL Number	MFCD12407408
ChemACX	X1819852-0
InChI	InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
SMILES	CS(=O)(=O)c1ccc(c(c1)Cl)C(=O)Nc2ccc(c(c2)c3ccccn3)Cl

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