It was found to be an effective inhibitor of JB6 cell transformation. Sarcophine is acetylcholine esterase and ATPase inhibitor.
From the soft bodied coral Sarcophytum glaucum a crystalline compound-sarcophine, which is believed to be one of the repellents protecting the coral against predators, was isolated.?
The recent study showed sarcophine-diol's possible use in prevention of skin cancer to consider its potential as a tool in therapies to actually treat skin cancer. Sarcophine-diol induced apoptosis, or programmed cell death in cancer cells in this study. But sarcophine-diol didn't induce what scientists call necrosis, or the premature death of healthy cells. The experiment also looke at whether sarcophine-diol treatments could increase what is called DNA fragmentation, considered a biochemical hallmark of apoptosis.
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Product References
Sarcophine, a new epoxy cembranolide from marine origin, J. Bernstein, et al., Tetrahedron, vol. 30, issue 16 (1974)
Sarcophine-diol, a Chemopreventive agent of skin cancer, inhibits cell growth and induces apoptosis through extrinsic pathway in human epidermoid carcinoma A431 cells, Xiaoying Zhang, et al, Transl Oncol. 2(1):21-30 (2009)
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