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Selective protein tyrosine kinase Syk inhibitor (IC50~10 M). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of Fc R1-mediated signaling. Besides that it works as activator of human deacetylase SIRT1.A natural stilbene and an analogue of Resveratrol (Prod.# R-1014). Besides antioxidative effects, piceatannol exhibits potential anticancer properties as shown by its ability to suppress proliferation of a wide variety of tumor cells, including leukemia, lymphoma; cancers of the breast, prostate, colon and melanoma. Also inhibits JAK-1 and Syk kinase; blocks adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Originally isolated from Euphorbia lagascae.

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• ORIGINAL ARTICLES:?Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells,?Keun Hwa Choi, et al. Cardiovasc Res. Mar 2010.?85: 836 - 844.
• PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS:?Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils,?Yoshihiro Kuwano, et al. Blood. Jul 2010.?116: 617 - 624.

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