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Rapamycin | CAS [53123-88-9] | Antibiotics| Immunosuppressant which has been sh

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Rapamycin | CAS [53123-88-9] | Antibiotics| Immunosuppressant which has been sh

品牌：AG Scientific

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規(guī)格：5 mg

貨期：

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CAS:53123-88-9Formula:C51H79NO13MW:914.2Appearance:WhitepowderPurity:99%

商品詳情參考文獻(xiàn) 相關(guān)資料

Rapamycin (also known as Sirolimus) is macrocyclic lactone produced by the bacterium?Streptomyces hygroscopicus?isolated from soil samples from Easter Island. Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin has antirejection properties without the side effects associated with other antirejection agents.?Rapamycin binds to a specific protein, Target of Rapamycin (TOR).?TOR is serine/threonine kinase.?TOR (mTOR) forms two major complexes: mTORC1,and mTORC2.?The mTORC1 consists of mTOR, Raptor, mLST8, FKBP38, PRAS40, and Deptor, and through specific binding of rapamycin to FKBP12, rapamycin inhibits the activity of mTORC1 leading to a decrease in protein synthesis, increased autophagy and inhibition of cell growth.?Recent studies and investigation in mice have demonstrated the potential of Rapamycin to slow aging. Rapamycin is being tested in dogs for its anti-aging properties.

Additional Information

Synonyms	RAPA, Rapamune, Sirolimus, AY-22989, NSC-226080
Product #	R-1018
CAS #	53123-88-9
Chemical Name	(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34AS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34A-HEXADECAHYDRO-9,27-DIHYDROXY-3-[(1R)-2-[(1S,3R,4R)-4-HYDROXY-3-METHOXYCYC LOHEXYL]-1-METHYLETHYL]-10,21-DIMETHOXY-6,8,12,14,20,26-HEXAMETHYL-23,27-E
Formula	C₅₁H₇₉NO₁₃
MW	914.2
Appearance	White powder
Purity	99%
Solubility	Clear colorless solution at 50 mg/ml in Ethanol or DMSO
Melting Point	183-184°C
Storage Temp	-20°C
Therapeutic Area	Autoimmune Diseases, Infectious Diseases
Use	Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor is used to prevent rejection in organ transplantation

Additional Information

Merck Index	13.8202.2001
MDL Number	MFCD00867594
ChemACX	X1000584-2
InChI	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC