Ponasterone A?is an Insect steroid hormone involved in regulating metamorphosis. It is an analog of ecdysone A and a member of the ecdysteroid family with similar properties to muristerone A. It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system.
Ponasterone A is a highly bioactive ligand that has demonstrated sustained release and transgene expression in vivo.?Ponasterone A?is?a?potent?regulator?of?gene expression?in cells and?transgenic animals,?enabling?reporter genes?to?be?turned?on?and?off rapidly. It inhibits cell growth?and increased?cell number?at?the?G1 phase. Treatment of?cells?with?the?synthetic?ecdysone?analog?ponasterone A, induced expression of GFP-MKK7(3E) and resulted in sustained activation of endogenous JNK, but neither of the other endogenous MAPK's, ERK orp38.
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