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Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an ICvalue of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had ICvalues of 3.2-8.5 M.

Additional Information

Synonyms	2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid
Product #	P-2377
CAS #	315183-21-2
Chemical Name	2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid
Formula	C23H28N4O2
MW	392.49
Appearance	White Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO
Melting Point	250.41 °C
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	PAC 1 is a procaspase-activating compound, which in turn produces caspase-3

Additional Information

MDL Number	MFCD03302441
ChemACX	X1579428-6
InChI	InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16-
SMILES	C=CCc1cccc(c1O)/C=NNC(=O)CN2CCN(CC2)Cc3ccccc3