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Oligomycin A mitochondrial ATPases Inhibitor, Oligomycin A lysosome acidificati

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Oligomycin A mitochondrial ATPases Inhibitor, Oligomycin A lysosome acidificati

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:579-13-5Formula:C45H74O11MW:791.1Appearance:WhitetoOff-whitepowder(Lyophilisate).Purity:95%

商品詳情參考文獻(xiàn) 相關(guān)資料

Oligomycin A is a component of the oligomycin complex (O-1060). It is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration.?Oligomycin A inhibits?ATP synthase by blocking its proton channel (Fo subunit), which is necessary for?oxidative phosphorylation?of?ADP?to?ATP?(energy production). The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the?electron transport chain however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial coupling. This process occurs due to the?facilitated diffusion?of protons into the?mitochondrial matrix?through an?uncoupling protein?such as?thermogenin, or?UCP1.

Oligomycin A stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Oligomycin A also induces autophagy in the IPLB-LdFB insect cell line.

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Additional Information

Product #	O-1063
CAS #	579-13-5
Chemical Name	(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ETHYL-7,11,14,15-TETRAHYDROXY-6'-((R)-2-HYDROXYPROPYL)-5',6,8,10,12,14,16,28,29-NONAMETHYL-3',4',5',6'-TETRAHYDRO-2,26-DIOXASPIRO[BICYCLO[23.3.1]NONACOSA[4,18,20]TRIENE-27,2'-
Formula	C₄₅H₇₄O₁₁
MW	791.1
Appearance	White to Off-white powder (Lyophilisate).
Purity	95%
Solubility	Soluble in ethanol, methanol, DMF, or DMSO. Poor water solubility.
Melting Point	140-141°C
Storage Temp	Store Desiccated at -20°C. Protect from light.
Therapeutic Area	Infectious Diseases
Use	A mitochondrial ATPase inhibitor use as antibiotics, antifungal activities.

Additional Information

Merck Index	13.6902.2001
MDL Number	MFCD00065705
ChemACX	X1094055-9
InChI	InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1
SMILES	CC[C@H]1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C