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Cell-permeable. A potent protein kinase inhibitor with a 330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric on p38 MAPK.

Additional Information

Synonyms	1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Product #	D-2294
CAS #	285983-48-4
Chemical Name	1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Formula	C31H37N5O3
MW	527.66
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Inflammatory Diseases
Use	Doramapimod is a highly selective p38a MAPK inhibitor to TNF-a for active in Crohn's disease

Additional Information

MDL Number	MFCD09752957
ChemACX	X1511901-0
InChI	InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
SMILES	Cc1ccc(cc1)n2c(cc(n2)C(C)(C)C)NC(=O)Nc3ccc(c4c3cccc4)OCCN5CCOCC5