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Quinomycin A CAS 512-64-1 HIF-1 Inhibitor stops tumor progrssion

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Quinomycin A CAS 512-64-1 HIF-1 Inhibitor stops tumor progrssion

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:512-64-1Formula:C51H64N12O12S2MW:1101.3Appearance:WhitetoOff-WhiteSolidPurity:99%(HPLC)

商品詳情參考文獻相關(guān)資料

Quinomycin A, aka Echinomycin?is a cyclic depsipeptide metabolite, Quinomycin A has broad activity against bacteria, fungi, and viruses. Also used as anti-tumor agent. Recent studies show Quniomycin A to be a potent inhibitor of Hypoxia-inducible factor-1 (HIF-1), HIF-1 plays an essential role in tumor progression metastasis. Quinomycin is toxic and possibly mutagenic, extreme caution is required when handling.

Additional Information

Synonyms	Echinomycin, Actinoleukin, 1491, 59266, X 948, X 53III
Product #	Q-1112
CAS #	512-64-1
Chemical Name	N-(2-QUINOXALINYLCARBONYL)-O-[N-(2-QUINOXALINYLCARBONYL)-D-SERYL-L-ALANYL-3-MERCAPTO-N,S-DIMETHYLCYSTEINYL-N-METHYL-L-VALYL]-D-SERYL-L-ALANYL-N-METHYLCYSTEINYL-N-METHYL L-VALINE (81)-LACTONE CYCLIC (37)-THIOESTER
Formula	C₅₁H₆₄N₁₂O₁₂S₂
MW	1101.3
Appearance	White to Off-White Solid
Purity	99% (HPLC)
Solubility	Soluble in 100% Ethanol, Methanol, DMF, DMSO, Insoluble in Water
Therapeutic Area	Oncological Disorders
Use	Quinomycin A to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3

Additional Information

MDL Number	MFCD00156105
ChemACX	X1009705-7
InChI	InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)/t27-,28-,35+,36+,37?,38-,39-,40?,51?/m0/s1
SMILES	C[C@H]1C(=O)N(C2CSC(C(C(=O)N([C@H](C(=O)OC[C@H](C(=O)N1)NC(=O)c3cnc4ccccc4n3)C(C)C)C)N(C(=O)[C@@H](NC(=O)[C@@H](COC(=O)[C@@H](N(C2=O)C)C(C)C)NC(=O)c5cnc6ccccc6n5)C)C)SC)C

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