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PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases with 10,000-fold selectivity over ZAP-70 and JAK2.PP2 strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100M) and JAK2 (50M).A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LT2 Gonadotrope Cells.VASCULAR BIOLOGY Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity .PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant.Binding of IgG-Opsonized Particles to FcR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation.

Additional Information

Synonyms	4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4,d]pyrimidine
Product #	P-1103
CAS #	172889-27-9
Chemical Name	1-tert-Butyl-3-(4-chlorophenyl)- 1H-pyrazolo[3,4-d]pyrimidin-4-amine
Formula	C15H16ClN5
MW	301.8
Appearance	Off White Solid
Purity	98%
Solubility	Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility
Melting Point	214-216 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	PP 2 is an effective and selective inhibitor of c-Src family kinases use in cervical cancer

Additional Information

MDL Number	MFCD01568210
ChemACX	X1486321-1
InChI	InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
SMILES	CC(C)(C)n1c2c(c(n1)c3ccc(cc3)Cl)c(ncn2)N