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Cell-permeable. A potent and selective γ-secretase inhibitor (IC= 17 nM) .Displays 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A40 and A42 peptides (ICvalues are 48 and 67 nM respectively in human neuroblastoma cells).

Additional Information

Synonyms	5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Product #	L-2369
CAS #	292632-98-5
Chemical Name	5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Formula	C39H52N4O6
MW	672.85
Appearance	Liquid
Purity	98% by HPLC
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Cell-permeable. A potent and selective γ-secretase inhibitor

Additional Information

MDL Number	MFCD03093402
ChemACX	X1270552-5
InChI	InChI=1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32+,33+,34-/m1/s1
SMILES	CC(C)C[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N)NC(=O)[C@H](Cc2ccccc2)C[C@H]([C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)O