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A potent, cell-permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC=0.70 nM. Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys. Excellent antitumor agent in vivo.

Additional Information

Synonyms	4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
Product #	P-1653
Chemical Name	4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
Formula	C17H13BrN4O
MW	369.2
Appearance	Orange-yellow Solid
Purity	95%
Solubility	Soluble in DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer

Additional Information

MDL Number	MFCD02179207
ChemACX	X1498384-9
InChI	InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
SMILES	C=CC(=O)Nc1ccc2c(c1)c(ncn2)Nc3cccc(c3)Br