NHI-2 (1269802-97-2) is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50?in vitro?= 14.7 μM (NADH), 10.5 μM (Pyruvate).?NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50?= 22.2 μM normoxic and 4.0 μM hypoxic; LPC006 cells IC50?= 17.8 μM normoxic and 1.1 μM hypoxic) with increased efficacy in a cancer cells hypoxic environment.?LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.
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