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Lapatinib Ditosylate

品牌：AG Scientific

貨號：

規(guī)格：25 mg

貨期：

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CAS:388082-78-8Formula:C29H26ClFN4O4S.2C7H8O3SMW:925.46Appearance:YellowSolidPurity:99%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Lapatinib is a potent inhibitor of EGFR kinase (K = 3 nM), ErbB-2 kinase (K = 13 nM), ErbB-4 kinase (K = 347 nM). Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive breast cancer models.

Additional Information

Synonyms	GW-57201, Tykerb, Tyverb
Product #	L-2371
CAS #	388082-78-8
Chemical Name	BIS(4-METHYLBENZENE-1-SULFONIC ACID) N-(3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYL)-6-(5-([(2-METHANESULFONYLETHYL)AMINO]METHYL)FURAN-2-YL)QUINAZOLIN-4-AMINE
Formula	C₂₉H₂₆ClFN₄O₄S.₂C₇H₈O₃S
MW	925.46
Appearance	Yellow Solid
Purity	99% by HPLC
Solubility	DMSO (200 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Lapatinib Ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases.

Additional Information

MDL Number	MFCD09264195
ChemACX	X1616542-3
InChI	InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;21-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);22-5H,1H3,(H,8,9,10)
SMILES	O=S(=O)(O)c1ccc(cc1)C.O=S(=O)(O)c1ccc(cc1)C.Fc1cccc(c1)COc2ccc(cc2Cl)Nc5ncnc4c5cc(c3oc(cc3)CNCCS(=O)(=O)C)cc4

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