KT5823 a staurosporine-related protein kinase inhibitor, is a K-252 compound. KT5823, is an?in vitro?inhibitor of cGK, has also been used in numerous studies with intact cells to implicate or rule out the involvement of this protein kinase in a given cellular response. KT5823 Inhibits cGMP-dependent Protein Kinase Activity?in Vitro?but not in Intact Human Platelets and Rat Mesangial Cells.?
KT5823, has been shown to increase thyroid - stimulating hormone-induced Na+/I-?symporter expression, and thus iodide uptake, in thyroid cells. KT5823- mediated effects on Na+/I- symporter activity and glycosylation are also observed in breast cancer cells as well as human embryonic kidney cells expressing exogenous NIS.?
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