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kainic chemical structure kainate receptors selective agonist, kainic acid natu

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kainic chemical structure kainate receptors selective agonist, kainic acid natu

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CAS:487-79-6Formula:C10H15NO4MW:213.23Appearance:WhitetoOffwhitepowderPurity:>99%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Kainic acid is a natural marine product originally isolated from the red marine alga?D. Simplex. It is a potent central nervous system stimulant, acting through specific kainate receptors?and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice.?Kainic acid is utilised in primary neuronal cell cultures?and acute brain slice preparations?to study the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics.

Additional Information

Synonyms	(-)-a-Kainic Acid
Product #	K-1013
CAS #	487-79-6
Chemical Name	(2S,3S,4S)-3-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Formula	C₁₀ H₁₅ N O₄
MW	213.23
Appearance	White to Off white powder
Purity	>99% by HPLC
Solubility	Soluble in water (10 mg/mL)
Storage Temp	Store desiccated at Room Temp.
Therapeutic Area	Neurological Disorders
Use	An excitatory and excitotoxic glutamate-mimic kainate receptor agonist used in epilepsy

Additional Information

MDL Number	MFCD00077806
ChemACX	X1063761-9
InChI	InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
SMILES	CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O

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