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Pyrintegrin---CellSurvivalEnhancer

品牌：Xcessbio

貨號(hào)：M60028-2s

規(guī)格：2 mg solid

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Pyrintegrin---CellSurvivalEnhancer

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	451.54
Formula:	C₂₃H₂₅N₅O₃S
Purity:	≥98%
CAS#:	1228445-38-2
Solubility:	DMSO up to 100 mM
Chemical Name:	N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.

How to Use:

In vitro: Pyrintegrin was used at 3-5 μM concentration in cell culture.
In vivo: n/a

Reference:

1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.

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Products are for research use only. Not for human use.

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