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DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is a methyltransferase involving in methyl group transference. The epigenetic modification is important for embryonic development, imprinting, and X-chromosome inactivation. DNMT3A has been shown to interact with protein like HDAC1 (1), Myc (2), Protein inhibitor of activated STAT2 (3) etc.

Reference:

• 1. Fuks, F et al. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.(2001) EMBO J. 20(10):2536–44.
• 2. Brenner, C et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor.(2005) EMBO J. 24(2):336–46.
• 3. Ling, Y et al. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.(2004) Nucleic Acids Res. 32(2):598–610.