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MI-2,Menin-MLLInhibitor

品牌：Xcessbio

貨號：M66046-2s

規(guī)格：2mg solid

貨期：

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MI-2,Menin-MLLInhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	375.55
Formula:	C₁₈H₂₅N₅S₂
Purity:	≥98%
CAS#:	1271738-62-5
Solubility:	DMSO up to 100 mM
Chemical Name:	4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

MI-2 is a potent and specific Menin-MLL inhibitor with an IC₅₀?~446 nM. It specifically binds to Menin and inhibits Menin’s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein–mediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.

How to Use: