最近最新的日本中文MV_麻豆出品视频在线_超pen个人视频97_国产精品第一国产精品_国产香蕉片_免费看麻豆文化传媒_奶大灬舒服灬太大了一进一出_人妻激情偷乱一区二区三区

Biological Activity:

Hydroxychloroquine (HCQ) is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment
has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence. HCQ was an effective growth inhibitor of human RCC cell lines, inhibiting growth, promoting apoptosis, and effecting cellular metabolism. HCQ altered the levels of the mTORC1 activation marker phospho-S6 and that this
effect was mediated by a different mechanism than that observed for the mTOR inhibitor RAD001. HCQ is also a potent inhibitor of TLR9, prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo.

How to Use:

In vitro: Hydroxychloroquine (HCQ) was used at 50-100 μM final concentration in various assays.
In vivo: Hydroxychloroquine (HCQ) can be dosed to mice orally at 50 mg/Kg once per day.

Reference:

• 1. Lee HO, et al. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. (2015) PLoS One. 10(7):e0131464.?
• 2. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. (2014) Mol Pharmacol. 85(3):429-40.?