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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

品牌：Xcessbio

貨號(hào)：M60182-2s

規(guī)格：2 mg solid

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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	499.52
Formula:	C₂₃H₂₅F₄N₃O₃S
Purity:	≥98%
CAS#:	1627676-59-8
Solubility:	DMSO up to 100 mM
Chemical Name:	(R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC₅₀ ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.

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