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WAY-316606,SecretedFrizzled-relatedProtein-1(sFRP-1)Inhibitor

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WAY-316606,SecretedFrizzled-relatedProtein-1(sFRP-1)Inhibitor

品牌：Xcessbio

貨號：M60215-2s

規(guī)格：2 mg solid

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WAY-316606,SecretedFrizzled-relatedProtein-1(sFRP-1)Inhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	484.94
Formula:	C₁₈H₁₉F₃N₂O₄S₂.HCl
Purity:	≥98%
CAS#:	423148-78-1
Solubility:	DMSO up to 100 mM
Chemical Name:	5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC₅₀?~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.

How to Use:

In vitro:? WAY-316606 was used at 1-10 μM final concentration in various in vitro assays.
In vivo:??n/a

Reference:

1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.

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