Biological Activity:
AR7 is a specific and potent RARα antagonist (IC50 < 100 nM) to stimulate Chaperone-mediated autophagy (CMA).It is a synthetic derivative of all-trans-retinoic acid developed through the structure-based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging and in age-related disorders (for example, neurodegenerative diseases and diabetes). AR7 working as a chemical enhancement of CMA protects cells from oxidative stress and from proteotoxicity, and supports a potential therapeutic opportunity when reduced CMA contributes to cellular dysfunction and disease. AR7 is the first chemical compound that affects CMA has the selectivity for this pathway without affecting macroautophagy.
How to Use:
In vitro:? AR7 was suggested to be used at 5-20 μM final concentration in vitro and in cellular assays.
In vivo: ?n/a
Reference:
? ?
? ??
Products are for research use only. Not for human use.?
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
sitemap 細(xì)胞庫(kù)查詢 危險(xiǎn)品圖標(biāo) 本公司網(wǎng)站所展示銷售的產(chǎn)品僅供科研！
滬公網(wǎng)安備 31011202007338號(hào)
